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Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation problems (such as Raynaud's disease), certain mental/mood conditions (such as agitation, psychosis), personal/family history of mental/mood disorders (such as bipolar disorder, depression, psychotic disorder, suicidal thoughts), heart problems (including irregular heartbeat/rhythm, coronary artery disease, heart failure, cardiomyopathy,...

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The tricyclic antidepressants and bupropion (Wellbutrin) are not FDA-approved for treatment of ADHD but are often used off-label. The tricyclic antidepressants affect levels of norepinephrine while bupropion affects levels of both norepinephrine and dopamine. Imipramine and desipramine are the most commonly used tricyclic antidepressants. However nortriptyline is also effective.

The individual glycoconjugates are compounded to formulate the vaccine, Prevnar. Potency of the formulated vaccine is determined by quantification of each of the saccharide antigens, and by the saccharide to protein ratios in the individual glycoconjugates.

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